CRC is the second-leading cause of cancer-related death. CRC is on the rise in people aged 45 to 49. That's why it's important to screen when due.


45 or older? It's CRC screen time.

Cologuard is FDA approved to screen for CRC in average-risk adults beginning at 45. It's noninvasive and easy to use, so there's no reason to put it off. Rx only. Learn more below.

Ask your healthcare provider about screening with Cologuard today


Cologuard uses the DNA in your stool to find 92% of colorectal cancers.*

*The clinical study was conducted in patients 50 and older. In the clinical study, 13% of patients received false positive results and 8% received false negative results.


Currently, 74% of Cologuard patients 45-49 have had no out-of-pocket cost for screening. Many national and regional payers have begun paying for CRC screening at 45. For more details, visit the Cologuard insurance page

†Exact Sciences estimate based on historical patient billing. Rate of coverage varies by state and region. Exceptions for coverage may apply, only your insurer can confirm how Cologuard would be covered for you.

Cologuard is intended to screen adults 45 years of age and older who are at average risk for colorectal cancer by detecting certain DNA markers and blood in the stool. Do not use if you have had adenomas, have inflammatory bowel disease and certain hereditary syndromes, or a personal or family history of colorectal cancer. Cologuard is not a replacement for colonoscopy in high risk patients. Cologuard performance in adults ages 45-49 is estimated based on a large clinical study of patients 50 and older.

The Cologuard test result should be interpreted with caution. A positive test result does not confirm the presence of cancer. Patients with a positive test result should be referred for diagnostic colonoscopy. A negative test result does not confirm the absence of cancer. Patients with a negative test result should discuss with their doctor when they need to be tested again. False positives and false negative results can occur. In a clinical study, 13% of people without cancer received a positive result (false positive) and 8% of people with cancer received a negative result (false negative). Rx only.

See Important Risk Information »

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